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Furthermore, the specific mechanisms by which estrogen influences brain function in the context of menopause, especially in terms of how different ERs mediate these effects, are still not fully understood

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[86] demonstrated that combined dasatinib and fisetin treatment in aged rhesus monkeys significantly reduced epidermal p16 + and p21 + senescent cells without adverse effects, confirming the safety and efficacy of combination senolytic therapy in primates